When the Tablet of Akmenrah seems to be causing problems for his old friends, the exhibits at the Museum of Natural History, former security guard Larry Daley travels to the British Museum to solve the mystery, meeting new characters along the way.

On the planet Cybertron, a war was waged between the Autobots and the Decepticons for control of the Allspark, a mystical talisman that would grant unlimited power to whoever possessed it. The Allspark is smuggled off the planet, but Megatron goes in search of it. He tracks it to Earth and his desire for power sends him into the Arctic Ocean. The sheer cold forces him into a paralyzed state. His body is later recovered, and before going into a comatose...

When an alien disguised as a teenager on Earth discovers that three of the last remaining members of his species have been killed, he uncovers hidden connections to the others of his race and fights the enemies aliens who have been sent to kill them.

When a childless baker and his wife ask a witch to reverse a curse on their family tree, she demands that they retrieve items from a variety of fairy tale characters before she will grant their wish.